Currently, if you open a folder from within Sublime a new window is created with the folder opened and the old window is kept open. An option to always replace the old window or open a folder in the current window would be neat.

Ruby syntax highlighting for extended regexp (which can contain whitespace and comments) is not working - the four comments should all have the same grey color. This is valid Ruby code which executes just fine. 

Command-L is more common than Command-G for "jumping to a line". It's used by TextMate and Xcode. Would be nice if some of the other similar shortcuts were the same... and ones that are missing are filled in (like Command-U for upper case, or Command-Shift-U / Command-L for lower case).

I know Control might be better for column select, but Xcode/TextEdit/TextMate use Option for column select (TextMate being the only one to edit on multiple lines, the other apps can at least copy/delete). This one might be better to keep as Control, but then again you might be getting suggestions about column select over and over again.

I don't think Command-Option-F makes sense for full screen. Anything-F is usually find related. Command-Enter is used commonly in games (Command-Shift-F is used in Firefox). This one is tough... I know Lion is going go have "full screen support".

For the most part everything else seems spot on.

ST2 looks great on my high-resolution desktop display and my HDTV alike: except that the font used in the tabs and on the status bar is so small as to be illegible.  I realize that it's possible to tweak it in the .sublime-theme, but the way widgets are mapped to areas of the screen is somewhat mysterious (I figured it out once, blew away my config, and haven't managed to get it working again).

On OSX you can set a "label" to a file or folder that will show through as a background color everywhere. Would be nice if these labels could be kept on the sidebar and tabs.

Often a file contains the name of a second file, and you would like to open the second file.
Like "gf" command on Vim

Thanks in advance

Ctrl+Space on Mac OS X opens the Spotlight search box by default. While this can be changed, it would be nice if the default keyboard shortcut for code completion in Sublime Text would not clash with it.