Frequent beachballs of death on OSX

I'm getting lots of beachballs while using ST2 (2.0.1 build 2217). It seems that over time those are getting more frequent. Usually it spins for 3-5 seconds, but rarely it persists for 30-60 seconds, at which point I usually lose patience and kill ST2. No "slow plugin" alert appears when this happens. I have no idea how to debug this further. Any ideas?